“作为网关或者代理工作的服务器尝试执行请求时，未能及时从上游服务器（URI标识出的服务器，例如HTTP、FTP、LDAP）或者辅助服务器（例如DNS）收到响应。“ — wikipedia

“The server, while acting as a gateway or proxy, did not receive a timely response from the upstream server specified by the URI (e.g. HTTP, FTP, LDAP) or some other auxiliary server (e.g. DNS) it needed to access in attempting to complete the request.
Note: Note to implementors: some deployed proxies are known to return 400 or 500 when DNS lookups time out.“ — ietf